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Is AstraZeneca stronger? The immune response was compared with that of Pfizer

The good news came: a Pfizer It is the same in elderly people after a single dose of AstraZeneca COVID-19 Antibody production Experienced researchers, however After AstraZeneca vaccination, the cellular immune response is more extensive and stronger.

The Preprints with Lancet page published an outstanding English study comparing the two vaccines in 165 elderly subjects aged 80-96 The first dose In the fifth week following the adjustment Immune response Indications. This is also great because they are two completely different vaccines: Pfizer / BioNTech is an mRNA, while the AstraZeneca vaccine is a vector based vaccine for adenoviruses.

a Pfizer Vaxina Antibody response against elevated SARS-CoV-2 protein in vaccines 93 percent (Average antibody titer: 19.3 units / ml), while AstraZeneca In the case of the vaccinated vaccine 87 percent (Average antibody titer is 19.6 units / ml).

Wondering how much antibody is in your blood after the vaccination? This test shows

AstraZeneca stimulates stronger T cell production

A high protein T-cell immune response was observed in 12% of those vaccinated with Pfizer / BioNTech, compared to 31% of those vaccinated with AstraZeneca, and For AstraZeneca, the average response was three times that observed with Pfizer / BioNTech.

The immune response after vaccination has also been shown to be the same He has a previous Covid infectionIn previous infections, immune responses were stronger.

The relationship between these findings and clinical protection is currently unclear. Writes Zabolux Dobson, pharmacist.

What are the cells involved in the acquisition of immunity?

Many cells are involved in achieving immunity, and these are the main contributions to immune protection:

  • Antibodies: Proteins circulating in the blood that recognize and neutralize foreign substances such as viruses
  • Auxiliary T cellsHelps identify pathogens.
  • Killer T cells: They kill pathogens.
  • B cells: It produces new antibodies when the body needs them.
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Currently, the post-vaccination test for SARS CoV2 is also available to the general public, but it is good to know that this test “only” shows how much protein binds to coronavirus receptors in venous blood. (Protein S) Specific IgG antibody level. Regarding the cellular immune response – mentioned in the research above – this test does not give any results.


Barry, Helen Marie, Bruton R et al. Single vaccination with BNT162b2 or ChAdOx1 in the elderly stimulated production of equivalent antibody but improved cellular responses after ChAdOx1. Available on SSRN:

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